The story follows the struggles of a teenage girl after she finds herself turning into a lycanthropy-leopard and having to battle her newly found predatory instincts.

Her biology teacher, Ms. Sonehara, has a peculiar interest in the birthmark, and it fires up when her childhood friend, Shin'ya Mizushima, tries to make a move on her.

Written and illustrated by Chie Shinohara, Purple Eyes in the Dark was serialized in Shōjo Comic magazine from 1984 to 1986 and later published in Japan in 12 tankōbon volumes by Shogakukan.

[3] EMI Music released two albums for Purple Eyes in the Dark using songs written by Linda Hennrick.

Vocal tracks included performances by Shoko Yamagiwa, Derek Jackson, and Seki Mayumi.