It is set in a post-apocalyptic future, long enough after a meteorite hits Earth that new species have evolved, and follows the struggles of five groups of young adults to survive after they are revived from cryonic preservation.

When astronomers predict that the Earth will be hit by a meteorite, the world leaders meet to develop a plan for human survival called the Seven Seeds project.

Each group consists of seven members, who are not told about what will happen before they are placed in cryonic preservation, and one adult guide who is trained in wilderness survival.

Awoken from the cryogenic sleep many years later, the young men and women find themselves amidst a hostile environment bare of any human life.

[3] In addition, sea levels have risen greatly: downtown Yokohama is completely underwater,[4] only the top hand of the statue in Nagasaki Peace Park is above the surface of the ocean.

[5] The geography of Japan has changed as well: after an eruption of Mount Aso, Kyūshū has been split into two islands,[6] and the Kansai region is separated from central Honshū by a wide strait.

[2] The series depicts a Japan in which, as a result of the new environment and mass extinctions, ecosystems have changed and several new species of animals and plants have evolved.

[8] In the Kansai region, Fall group domesticates flightless birds about the size of a chicken and sheep that have grown to resemble llamas, which can be ridden, milked and shorn for wool.

[9] According to Akio, corn is the only crop from their seed cache that grows in the area's soils, but Fall group also cultivates a variety of tobacco with a narcotic effect when smoked.

[2] In the southern part of central Honshū, Natsu, Arashi, and Semimaru of Summer group B cross a desert with cactus scrub.

Throughout the region they find remains of large reptiles that revive from estivation during the rainy season, which remind Natsu of velociraptors from Jurassic Park.

[10] These "dinosaurs", as the characters call them, have grassland and woodland varieties, and during the rainy season are the dominant predator from the south coast to at least as far north as Tokyo.

[11] On land, there are giant insects the characters call "boat beetles" and swarms of bees with stings that are painful but not deadly, which force the group to live on rafts off-shore.

The characters find the climate changed as well, as it is too overcast to see the stars for the first two weeks after they are awake, even though it is spring, a season that in the present day is noted for clear weather.

[13] In northern Honshū near Sendai, Natsu, Arashi and Semimaru of Summer group B find the first flowers they have seen during their journey over most of the length of Japan.

[14] In southern Hokkaidō, Winter group encounters grasslands populated by many mammals they do not know, including small-eared rodents, herds of unknown ruminants, and tigers with saber-teeth.

Several voice actors who would later be cast in the anime adaptation of 7 Seeds were first featured on the drama CD, including Kazuhiko Inoue as Kaname Mozunoto, Shō Hayami as Takashi Sugurono, Nozomu Sasaki as Takahiro Aramaki, and Katsuyuki Konishi as Semimaru Asai.

[39] A stage play adaptation of the manga, titled 7 Seeds: Spring Chapter (7SEEDS～春の章～), is scheduled to run from December 20–29, 2024, in Tokyo's Kokumin Kyōsai coop Hall / Space Zero.

The stage play will star Iori Sagara as Hana Sugurono, Naoki Kunishima as Haru Yukima, Ryosuke Yamamoto as Mansaku Tsunomata, Rio Sawada as Hibari Nigusa, Maasa Sudo as Chisa Taiami, Rento Nishimiya as Momotaro Nobi, Karen Aizome as Fujiko Amacha, Yojiro Murata as Dosei Yanagi, Ryo Taguchi as Takahiro Aramaki, and Hiroki Nakata as Kaname Mozunoto.