Having learned bookbinding under his father, Friedrich started a small book-store in Passau in 1819 and in 1822 founded a separate printing establishment.
Establishing business relations with prominent Catholic authors, he extended the range of his publications to all branches of literature, while paying special attention to theology.
Friedrich chose for his department liturgical publications, Karl German works, and Klemens the paper factory.
The success of Friedrich earned for him in 1870 the title Typographus S. R. Congregationis; the Vatican commissioned Pustet to print the editio typica of all the liturgical works.
Karl, who was a Privy Counsellor of Commerce, expanded the German publications: amongst those were the Regensburger Marienkalender and the illustrated family magazine, the Deutscher Hausschatz.