The biggest lakes in the district are Nevedro, Asho, Orleya, Veryato, and Losno.

[8] The Velikaya River served as one of the branches of the trade route from the Varangians to the Greeks, and the area was settled at least from the medieval times.

Afterwards, it was on the border between Russia (Grand Duchy of Moscow) and Poland, changing hands.

[9] On August 1, 1927, the uyezds were abolished and Pustoshkinsky District was established, with the administrative center in Pustoshka.

The governorates were abolished as well, and the district became a part of Velikiye Luki Okrug of Leningrad Oblast.

On July 23, 1930, the okrugs were also abolished and the districts were directly subordinated to the oblast.

On January 29, 1935, the district was transferred to Kalinin Oblast, and on February 5 of the same year, Pustoshkinsky District became a part of Velikiye Luki Okrug of Kalinin Oblast, one of the okrugs abutting the state boundaries of the Soviet Union.

On August 22, 1944, the district was transferred to newly established Velikiye Luki Oblast.

[10] On August 1, 1927, Kudeversky District with the administrative center in the selo of Kudever was also established.

The district was a part of Velikiye Luki Okrug of Leningrad Oblast.

The main agricultural specializations are milk and meat production, as well as potato growing.

The M9 highway which connects Moscow and Riga crosses the district from east to west.

The M20 highway connects St. Petersburg and Kiev, crossing the district from north to south.