Megacraspedus centrosema is a moth of the family Gelechiidae.

It is found in Australia, where it has been recorded from New South Wales and South Australia.

The forewings are fuscous with a shining white costal streak from the base to the apex, narrowed towards the extremities, the lower edge is straight and edged with dark fuscous.

There is an undefined rather broad streak of white suffusion along the dorsum and termen.

This article on a moth of the genus Megacraspedus is a stub.