Pymetrozine is an insecticide in the pyridine-azomethine chemical class, primarily utilized for controlling homopteran pests, such as aphids and whiteflies, in agricultural settings.

[4][5] Pymetrozine is a neuroactive insecticide that selectively affects chordotonal mechanoreceptors present in the legs of sap-feeding insects.

[8] These channels, which consist of two key protein subunits, play a crucial role in sensory signal transduction.

When pymetrozine binds to these channels, it alters their activity, leading to increased sensitivity and disruption of normal neuronal signaling.

[10] Pymetrozine is of low acute toxicity to humans, mammals, birds, aquatic organisms, and bees.