Qasim II Khan (Turki/Kypchak and Persian: قاسم خان ثانی; died 1532) was the ruler of the Astrakhan Khanate until 1532.
He was a son of Big Horde's khan Sayed Akhmad, and a grandson of Akhmat.
He is known to send a letter to Ottoman sultan Süleyman in 1531/1532.
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