[1] His father, actor and director Mohamed El Sheikh Najib [ar], and his mother, Khadija  El-Abed, a traditional Syrian folk dancer inspired his early curiosity about the stage.

[7] Sheikh Najib anchored his reputation with Layali al-Salhiya (Good Nights) in 2004, a Syrian crime drama with an all-star cast.

[8] The same year, he also appeared as Salah in director Hatem Ali's Al-Taghriba Al-Falastiniya, which dealt with the struggles of a Palestinian family over several generations.

[10] Sheikh Najib has also acted in several historical dramas, among them Salah El-Din El Ayoubi (2001),[11] Saqf el-Alam (Roof of the World) (2007), where he reprised the role of Antonio Banderas in the 1999 feature film The 13th Warrior, playing Ahmad bin Fadlan, and in Zaman el Barghout[12] (Time of the Flea) (2012), set in Syria during the French Mandate.

He also starred in romantic comedies such as Madraset el Hobb[14] (The School of Love) (2016), Yaret (I wish) (2016)[15] and Julia (2018),[16] where he played the role of a psychiatrist.

[17] In 2019, Sheikh Najib starred in two high-profile TV series: Syrian contemporary crime drama Massafet Aman (A Distance of Safety),[18] and Haramlek, whose intrigue was set among the background of the rise of the Mamluk in Egypt.

[2] In September 2020, he returned to host the third season of the hit talk show A'det Rigala (Men's Gathering) on Orbit Showtime Network (OSN), alongside Nicolas Mouawad and Khaled Selim.