The first Qosmio laptop was released on July 25, 2004 as the E15-AV101 with a 1.7 GHz Intel Pentium M CPU, 512 megabytes of DDR SDRAM, and a 15-inch XGA 1024x768 screen.

Toshiba's most powerful laptop has undergone many revisions, with focus shifting from high-end multimedia functionality to heavy gaming.

The last line under the Qosmio name, the X70 series, was released in 2013, featuring an Intel Core i7 processor with up to 32 gigabytes of DDR3 SDRAM and an Nvidia GeForce GTX 770M as well as a 17.3-inch Full HD display.

Released on February 7, 2007, the Toshiba F45 series was an upgraded line of F40 laptops with advertised features including Dolby Home Theater and a built-in subwoofer.

The basic specs included an Intel Core 2 Duo T5450 Processor at 1.66 GHz, with 2 megabytes of L2 cache attached to a 64-bit 667 MHz FSB.

[17] Released in 2013 was the Qosmio X70-A series, with a Nvidia GeForce GTX 770M graphics processor designed for gaming and multimedia usage.