Quantico Creek is a 13.7-mile-long (22.0 km)[1] partially tidal tributary of the Potomac River in eastern Prince William County, Virginia.

Quantico Creek rises southeast of Independent Hill, flows through Prince William Forest Park and Dumfries and empties into the Potomac at Possum Point.

John Smith in 1608 reported the existence of a Doeg community called Pamacocack on the banks of this creek, as well as on the directly opposite (Maryland) side of the Potomac.

This is thought to be a likely candidate for the place Henry Spelman was found living among the natives, which he reported was named "Nacottawtanke, but by our english cald [sic] Camocacocke".

Scottish settlers then established a settlement and port on the estuary of Quantico Creek downstream after the bars to Virginia's profitable tobacco trade were lifted by the Navigation Law of 1707.