[2] The Devil Dogs registered wins against college programs such as Virginia Tech, Georgetown, Rutgers, and Villanova, and were the only team to score a touchdown against the undefeated 1923 Michigan Wolverines.

The "Devil Dogs" football program began after World War I, encouraged by Marine Corps General Smedley Butler, for whom the team's stadium was later named.

[2] Before a crowd of 16,000 in Baltimore in 1921, the Marines defeated the Third Army Corps, who were coached by Major Dwight D. Eisenhower,[4] by a score of 20–0.

[10] The game with Third Army Corps was held in Baltimore before 50,000 fans including 12,000 Marines, the Secretaries of War and the Navy, Governors of Pennsylvania, Maryland and Virginia and 100 members of Congress.

[13] "Support for the team reached an all-time high during a game against the University of Michigan at Ann Arbor, during the Corps’ anniversary in 1923.

Tom Keady took over the head coaching duties for the 1925 season,[17] but Quantico didn't fare as well, finishing with a 6–3–1 record.

[19] In the 1965 season finale at Butler Stadium, Quantico (a two-touchdown underdog) pulled off an upset of Memphis State, 20–14.

[29] The program was discontinued by General Robert E. Cushman, Commandant of the Marine Corps, who stated that "continued personnel and financial support for football could not be justified" due to rising costs.

Multiple players and coaches with the team ultimately became general officers in the Marine Corps, including: Source:[2][19][31][36]