Francis Xavier Reagan (July 28, 1919 – November 20, 1972) was an American football player, coach, and college athletics administrator.

He played professionally for the New York Giants and the Philadelphia Eagles during a seven-season National Football League (NFL) career that spanned from 1941 to 1951.

Born in Philadelphia, Reagan was a star quarterback and defensive back at Northeast Catholic High School and led the team to championships in 1935 and 1936.

Standing 5'11" and 182 lbs., Reagan was a varsity player during George Munger's first three seasons as head coach of the Penn Quakers, from 1938 to 1940.

Reagan had one of the great individual performances of all time against Princeton on October 19, 1940, rushing for 200 yards, scoring five touchdowns and 31 points in a 46–28 victory at Franklin Field.

Sportswriter Grantland Rice called him "one of the two best running backs in college football", the other being Heisman Trophy winner Tom Harmon of the University of Michigan.