The film stars Mercedes Mason, Josh Cooke and Mattie Liptak as passengers on an airplane where the mutant rabies virus from the previous film is now spreading, forcing the plane to make an emergency landing at a terminal that is promptly surrounded by the government, trapping the passengers and crew as they search for answers and a means of escape.

[3] On a flight from Los Angeles to Kansas City, passenger Ralph Bundt becomes violent and attempts to enter the cockpit.

Ralph had been bitten by a lab rat, brought onto the plane by Henry, who claimed they were his classroom's pet hamsters.

As Henry tells Jenny that George is just confused, they are attacked by the escaped Ralph, but kill him with the help of Ed and Shilah.

Four heavily armed officers arrive to administer drugs to the group, but also release the infected passengers from their confinement.

He tells them about a quarantined building in Los Angeles that housed a lab for a group of bioterrorists and confirms that the drugs are only experimental antidotes.

After a struggle, Henry shoots and kills Ed, administers his trial antidote to himself and then kidnaps George to use him as a human shield.

Jenny uses the goggles and finds George near the tunnel, where he tells her the antidote has failed and that Henry is mutating into a rat-like infected, who appears and attacks her.

George escapes through the grate at the end of the drainage tunnel but Jenny cannot fit through the bars, and he reluctantly leaves her behind as she succumbs to the infection.

George discards the thermal vision goggles, through which Louise's infected cat is seen walking towards the Luxor Las Vegas hotel, implying that the plane landed at McCarran International Airport and that all efforts to contain the virus have failed.

In May 2010, a sequel to Quarantine began moving forward at Screen Gems with John Pogue writing and directing and Robert Green Hall returning as the film's makeup designer.

Instead Pogue opted to shoot the film handheld, in the style of filmmakers such as Rodrigo Prieto and Paul Greengrass.

Quarantine 2: Terminal received an approval of 67% on Rotten Tomatoes with an average rating of 5.42/10, based on 9 reviews.