It was released on September 4, 2015, as the second single from his third studio album, Los Vaqueros 3: La trilogía (2015).

[1] The music video was directed by Jessy Terrero and released on October 2, 2015.

"Que Se Sienta El Deseo" also reached number thirty-five on Mexican Espanol Airplay.

Wisin and Ricky Martin performed the song at the Latin Grammy Awards on November 19, 2015.

[5] "Que Se Sienta El Deseo" was covered by the contestants of Latin American singing competition series, La Banda.