"Adrenalina" received widely positive reviews from music critics, who complimented its danceable rhythm and noted its featured artists as two Latin icons.

It was commercially successful, reaching the top five in Mexico and Spain, and on the Billboard Hot Latin Songs chart in the United States.

On October 30, 2012, Univision revealed that reggaeton duo Wisin & Yandel had recorded a song entitled "Adrenalina" along with Jennifer Lopez and Ricky Martin.

Wisin explained that "Adrenalina" had originally been recorded for Lopez, but upon hearing the tones and the vibes, they decided to invite Martin: "We told him that it was an explosion of theme.

[2] In an interview with People en Español, Wisin talked about the collaboration: I am honored and extremely grateful to have created this partnership between Jennifer, Ricky and myself.

[5][6] A Spanglish version of the song was recorded under the same title by Martin featuring Lopez and Wisin; it was released for digital download and streaming by Sony Music Latin on February 25, 2014.

[19] Idolator's Mike Wass described it as "an infectious Latin-infused dance anthem" and Remezcla's Marcos Hassan called it an athem that is "impossible to resist".

[20][21] Velvet Music editorial team stated that the song made a lot of noise since it features "the two Latin giants" Lopez and Martin, who joined "the unknown" Wisin.

[22] An author of Primera Hora named Lopez and Martin "the most international and the most desired Puerto Rican couple of the moment",[23] while a writer of El Periódico de Catalunya introduced them as "two icons of Latin music in the US".

[15] Noelia Bertol from Cadena Dial ranked "Adrenalina" as one of "Ricky Martin six collaborations that have us moving the skeleton" and labeled it "a real great song".

"Adrenalina" spent a total of 26 weeks on the chart and marked Wisin's highest-charting and longest running single at the time, surpassing "Que Viva La Vida" (2013).

[51] On February 10, 2014, Wisin and Martin shared photos of themselves along with Dominican director Jessy Terrero, Ed Coriano, and Henry Quintero on the set of filming "Adrenalina" music video.

[52][53][54] Martin and Lopez continued sharing photos and videos from the set on Instagram, which included sensual scenes depicting the two singers.

The same as Lopez's several other music videos, "Adrenalina" visual includes street chases, leather and the lack of clothing, the underground atmosphere, and a final clandestine party, while according to E!

Idolator's Mike Wass described the two as "the most beautiful 40-somethings on earth", praising Martin's "pretty" look and Lopez's "famous" buttocks that "steal the show".

[65][66][67] On December 1, 2018, Wisin & Yandel invited Martin as a guest to their Como Antes Tour and the three singers performed "Fiebre" and "Adrenalina" together at the José Miguel Agrelot Coliseum in San Juan, Puerto Rico.

During the performance, Martin wore a black T-shirt with the flag of Puerto Rico drawn by his children, to raise funds for helping people and reconstructing houses, following Hurricane Maria.

[71] In the same year, Wisin and his team performed a medley of "Aullando", "Me niego", "Escápate Conmigo", and "Adrenalina" on the first season of American singing competition television series La Voz.