Route 109 is a Quebec provincial highway that runs through the western regions of Abitibi-Témiscamingue and Nord-du-Québec.

It begins at Route 117 in Rivière-Héva, proceeding north approximately 59 km (36.7 mi) to Amos.

From there, the highway extends 182 km (113.1 mi) to Matagami, where the road continues northwards as James Bay Road (French: Route de la Baie James).

The 182 km section of Route 109 between Saint-Dominique-du-Rosaire and Matagami winds through complete wilderness.

No services exist at all there, but extensive logging takes place along the section.