Route 218 is a two-lane east/west highway in Quebec, Canada.

Its western terminus is at the junction of Route 132 in Saint-Pierre-les-Becquets and its eastern terminus is in Saint-Michel-de-Bellechasse at the junction of Route 281.

From Saint-Pierre-les-Becquets to its junction with Autoroute 20, it runs southeasterly (except from a brief northeastern-bound concurrency with Route 226) until it reaches the Bécancour River, which it follows West on its North shore until Lyster, where it shares a concurrency with Route 116.

From there it turns northeasterly toward a concurrency with Route 271 in Sainte-Agathe-de-Lotbinière and its junction with Route 269 between Saint-Patrice-de-Beaurivage and Saint-Gilles, with both routes following the Beaurivage River downstream before separating at Saint-Gilles, where Route 218 crosses the river toward Saint-Lambert-de-Lauzon, where it crosses the Chaudière River.

Finally, it goes again northeasterly, roughly following the Boyer River toward Saint-Charles-de-Bellechasse and its terminus just south of Autoroute 20.