Saint-Camille-de-Lellis Saint-Magloire Saint-Philémon Armagh Saint-Raphaël Route 281 is a 75 km two-lane north/south highway in the Chaudière-Appalaches region in the province of Quebec, Canada.

Its northern terminus is in St-Michel at the junction of Route 132 and its southern terminus is close to Saint-Camille-de-Lellis at the junction of Route 204.

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