Route 391 is a provincial highway located in the Abitibi-Témiscamingue region in southwestern Quebec near the Ontario border.

The 90 km (56 mi) road runs from the junction of Route 101 near St-Édouard-de-Fabre and ends in Rouyn-Noranda at the junction of Route 117.

Between Lorrainville and Laverlochère-Angliers, it overlaps Route 382.

Near Rollet, it is also concurrent with Route 101.

This Quebec road, road transport or highway-related article is a stub.