Route 395 is a two-lane north/south highway located in the Abitibi-Témiscamingue region in Quebec, Canada.

It starts at the junction of Route 117 in Cadillac (now part of Rouyn-Noranda) and ends at the junction of Route 397 in La Morandière-Rochebaucourt.

It is briefly concurrent with Route 111 in Amos.

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