Quedlinburg was a district (Kreis) in the west of Saxony-Anhalt, Germany.

Neighboring districts are (from west clockwise) Wernigerode, Halberstadt, Bördekreis, Aschersleben-Staßfurt, Mansfelder Land, Sangerhausen and the district Nordhausen in Thuringia.

Parts of the districts of Blankenburg and of Aschersleben were added in 1994.

The northern part of the district is located in the Harz mountains.

The coat of arms were granted on September 24, 1990, replacing the older arms which only contained the knives of Quedlinburg.