There is also an Immediate Assessment Unit for local GPs and out-of-hours services, to send patients directly, without having to be processed through the Emergency Department.

The whole facility is operated by NHS Greater Glasgow and Clyde, [2][3] and is one of the largest acute hospital campuses in Europe.

[21] When the hospital opened its doors, locals nicknamed it the "Death Star" due to its star-shaped design, large size and the landing pad for aircraft on the roof.

[22][23][24] In February 2020, NHS Greater Glasgow & Clyde started legal proceedings against Multiplex, Capita Property & Infrastructure, and Currie & Brown for an estimated £73 million in losses and damages relating to technical issues at the Queen Elizabeth University Hospital and the Royal Hospital for Children.

With 256 beds and five floors, it replaced the Royal Hospital for Sick Children located in Yorkhill, Glasgow.

Firstly the larger INS building, which contains critical care, 6 operating theatres, diagnostic imaging services and 4 inpatient wards, as well as the Clinical Research Facility (CRF).

The second building is the Neurology Block, which contains an outpatient department, Clinical Neurophysiology, two inpatient wards and the West of Scotland Maxillofacial Prosthetics service.

The Physically Disabled Rehabilitation Unit (PDRU) is connected to the Neurology Block and provides specialist Neurorehabilitation services to NHSGGC patients.

With patient drop-off zones, access to bus services serving the city and its suburbs, a boardwalk connecting the adult and children's hospitals and a taxi stand.

[40] The adult, children and laboratory buildings within the hospital are equipped with a fleet of 26 automated guided vehicles (AGVs) to carry supplies, using dedicated lifts and a network of tunnels.