The Royal Hospital for Children, like the adjacent Queen Elizabeth University Hospital, was designed by Nightingale Associates,[1] with construction carried out by Brookfield Multiplex, who previously built Wembley Stadium.

[6][7] It was originally hoped the new hospital would be ready by 2014,[8] but medical services did not start to be transferred until 10 June 2015.

[10] The design included a part covered roof garden[11] where it was intended that young patients would be able to enjoy a range of activities in the fresh air.

In 2016 the roof garden play area was closed amid health and safety concerns.

With 256 beds and 5 floors, it replaced the Royal Hospital for Sick Children located in Yorkhill, Glasgow.