[1] It runs roughly north-south and is primarily a commercial and financial thoroughfare of the central business district.

[3] As part of the traditional financial district of Melbourne, Queen Street is home to many buildings listed on Victorian Heritage Register and/or classified by the National Trust of Australia.

These include: There are also many notable high-rise office buildings along Queen Street, including: On 8 December 1987 a gunman killed eight people and injured five others at the Australia Post offices at 191 Queen Street.

The gunman Frank Vitkovic eventually fell from a building window taking the death toll to nine.

[4] A memorial window for the victims is located at the General Post Office on Elizabeth and Bourke Streets.