In addition to regular graves, Queen of Heaven was the first area cemetery to have religious shrine sections.

One of these is the "Shrine of the Holy Innocents," where young victims of the 1958 Our Lady of the Angels School Fire are interred.

Queen of Heaven Mausoleum, at the northeast corner of the cemetery, has 30,000 crypts and 64 columbarium niches.

The Queen of Heaven mausoleum complex has room for over 33,000 bodies and was as of 2009 about 75 percent filled.

The art in the west wing of the main building was carried out mostly by DaPrato Studios of Chicago, with an international array of artists/architectural designers,(including a few from the Chicago area) artists such as: Italo Botti, Angelo Gherardi (Italy/US), Urano Bottari (Italy/US), Laurence Campbell (Ireland), Professor Emeritus Peter Bagnolo (Oak Park, Illinois), and a number of others.