It is located at the north end of the Queens Hospital Center campus, which extends west to Parsons Boulevard, east to 164th Street, and south to the Grand Central Parkway.

[2] The building was designed by Pei Cobb Freed & Partners and built by the New York City School Construction Authority.

[5] Among the building's facilities include 24 classrooms, 11 science labs, a 297-seat auditorium, cafeterias for students and teachers, a library, and an art studio.

[10] Until the opening of its current building, Queens Gateway was located in the former Jamaica Jewish Center on 87th Road near Parsons Boulevard and Hillside Avenue in Briarwood, across from Hillcrest High School.

District 29 contains Queens Village, St. Albans, Cambria Heights, Laurelton, Rosedale, and Springfield Gardens.

[21] The school offers numerous Advanced Placement (AP) courses in both science and humanities topics.

[21] The school also offers intramural sports, including basketball, soccer, floor hockey, and table tennis.

[21][23] The middle school had previously participated in the CHAMPS (Cooperative, Healthy, Active, Motivated, Positive Students) athletic league.

It first was housed in Richard Grossley Junior High School (JHS 8) on Merrick Boulevard in South Jamaica.

[26][34] In December 2001, the New York City Department of Education (DOE) announced plans to construct a new 800-seat building for Queens Gateway.

[11] Residents of the local community, however, opposed the plan due to fears of additional pedestrian and automobile traffic, loss of parking, and an increased strain on mass transit and police resources.

[11][38][39] On April 19, 2007, the members of Queens Community Board 8 (representing Hillcrest) unanimously vetoed the new school's construction.

[2][13] Although supported by the school's principal, the move received negative feedback from staff members who felt the expansion was too abrupt.