The school was opened in 2003 as South Texas Academy of Medical Technology in San Benito and changed its name in 2012 to South Texas Academy for Medical Professions (Medical Academy).

The school relocated to Olmito, Texas to its bigger campus which opened in 2015.

South Texas ISD Medical Professions is part of the South Texas Independent School District.

It has notable partnerships with Baylor College of Medicine, Harlingen Medical Center, Regional Academic Health Center, Texas State Technical College, Valley Baptist Medical Center and University of Texas at Brownsville and UTRGVSTISD - Med Tech

This article about a high school in Texas is a stub.