The show was created, written, and executive-produced by Mike Reiss, who also produced network cartoons The Simpsons and The Critic.

"[3] The title character, whose full name is Adam Seymour Duckstein (voiced by Jim J. Bullock), is a gay anthropomorphic duck who works as a nurse.

Queer Duck is known to gossip about anything and everything, especially on the phone while watching television, as shown on Oh Christ!, The Gaining of Herpes from Sparky and A Gay Outing.

When in heaven he finds out that famous icons like Socrates and Leonardo da Vinci are also gay, much to the chagrin of Jerry Falwell.

Queer Duck is not the most beloved child in his family and there are strong hints that his older brother Lucky is the most favored one, due to his heterosexuality.

In 2005, Queer Duck was voted among the 100 Greatest Cartoons in a poll conducted by the British television network Channel 4, ranking at #94.

The film reunites the original creators and cast of Queer Duck, plus special guest stars Conan O'Brien as himself; Tim Curry as Peccery the butler; Jeff Glen Bennett as the main antagonist, a homophobic bigoted priest named Reverend Vandergelding; Mark Hamill as a hot dog vendor; Bruce Vilanch as himself; Andy Dick as former drag queen Rex (formerly Regina); Jackie Hoffman as Broadway actress Lola Buzzard; April Winchell doing additional voices and David Duchovny as "Tiny Jesus".

The film concerns Queer Duck struggling with his sexuality and his love crisis between his longtime partner Openly Gator or the spunky Broadway actress Lola Buiszzard.