The game was designed by Amít Moshe based on his City of Mist system, with writing by Steven Pope and illustrations by Isa, who created the manga.

According to Jeffrey Dohm-Sanchez for ICv2, Queerz uses "power tag mechanics where any abilities, characteristics, resources, allies, or moves can be named by the player and invoked during play as an action.

"[4] In an interview with Egg Embry for EN World, Amít Moshe explained that "when the Queerz win they enter the Inner Space and hash out what made their enemies turn into villains, and eventually they become their allies.

They all have motives that make sense to them, and the process of dealing with them always involves grappling with those reasons, and the person they are, in order to figure out how to get through to them.

Using the creative tag-based engine of City of Mist, players can combine their own unique abilities with core moves like Slay, Strike a Pose, Care, Be Vulnerable, and Talk It Out, mixing anime action, light-heartedness, and drama at the table.