[1] Griffin was selected by the Denver Broncos of the National Football League with the 11th pick of the fourth round (108th overall) in the 2003 NFL draft.

and two touchdowns, in addition to catching 18 passes for 129 yards and one score, the injury caused him to drop to the bottom of the depth chart behind Mike Anderson, Tatum Bell and Ron Dayne.

On February 23, 2007, Griffin was chosen by the Hamburg Sea Devils as the second overall pick in the NFL Europa Free Agent Draft.

According to media reports, Roughriders' head coach Ken Miller was "so upset with Griffin following (the game) that he cut the former NFLer at the airport."

In July 2018, he left MSSU for the position of running backs coach for the University of Northern Iowa (UNI) Panthers.

[5] After one season at UNI, Griffin took a position as Assistant Football Coach (Running Backs) at Blinn College in Brenham, Texas.