[1][2] The town is named for the native Quepo Indians who inhabited the place in the colonial era.

[citation needed] The area was home to the native Quepoa people of this specific Costa Rican region.

south (in a straight line) from Costa Rica's capital, San José, but is 157 km from that city by road if going through the localities of Atenas, Orotina and Tárcoles.

Other villages are Anita, Bartolo, Boca Naranjo, Cañas, Cañitas, Cerritos, Cerros, Damas, Delicias, Espadilla, Estero Damas, Estero Garita, Llamarón, Llorona, Managua, Manuel Antonio, Marítima, Mona, Papaturro, Paquita, Pastora, Quebrada Azul, Rey, Ríos and Roncador.

[6] The district is covered by the following road routes: Quepos is the gateway to Manuel Antonio National Park.