It has been found in the states of Jalisco, Colima, Guerrero, Michoacán, and Oaxaca in southern Mexico.

[2][3][1] Quercus uxoris is a large deciduous tree up to 25 metres (82 feet) tall with a trunk often more than 100 centimetres (39 inches) in diameter.

The leaves can be as much as 26 cm (10 in) long, thick and leathery, broadly lance-shaped with numerous tapering teeth along the edges.

[2] Quercus uxoris is native to the mountains of southern Mexico, mostly in the Sierra Madre del Sur, with small outlier populations in the Chiapas Highlands and Sierra Madre de Chiapas of Chiapas in southeastern Mexico, and in the Sierra de Taxco and near Valle de Bravo in the Trans-Mexican Volcanic Belt of central Mexico.

[1] A population of the species in the montane mesophyll forest of Ojo de Agua del Cuervo, in Talpa de Allende municipality of Jalisco, is threatened by deforestation, illegal logging, and road-building which fragments habitat blocks.