The Polytechnic established its reputation among local government units as a show window and model technology-based institution paving the way for its recognition by the Technical Education and Skills Development Authority (TESDA) and developing a strong alliance with the Japan International Cooperation Agency (JICA).

[6] The university started offering bachelor's degree programs for entrepreneurial management, industrial engineering and information technology in the 2005–2006 academic year.

To support the K–12 initiative of the national government, the university started temporarily offering senior high school programs (ABM, STEM and TechVoc strands) through the enactment of City Ordinance SP-2308 in 2014.

The Commission on Higher Education in June 2021, formally recognized QCU through the awarding of institutional recognition (IR) to the university.

[11] The QCU Main Campus is located along Quirino Highway in Barangay San Bartolome, Novaliches.

The university also operates an Enterprise Development Center, from its main campus, designed to connect its entrepreneurship program with the needs of small and medium-scale businesses in the city.

[12] In 2006, the university opened its first satellite campus located inside the grounds of San Francisco High School in Barangay Sto.