Together with Primero, Segundo, Tercero, Cuarto, and Sexto, Quinto is one of the municipality's six original urban barrios.
[3] Quinto is an urban barrio located in the southern section of the municipality, within the Ponce city limits, and northeast of the traditional center of the city, Plaza Las Delicias.
[4] In terms of barrio-to-barrio boundaries, Quinto is bounded in the North by Sexto, in the South by Tercero, in the West by Segundo, and in the East by Machuelo Abajo.
Also, the Isabel II Marketplace (Plaza del Mercado de Ponce) is located here.
NRHP-listed landmarks in Barrio Quinto include the Font-Ubides House, the Mercado de las Carnes (Plaza Juan Ponce de León), and the old Spanish Military Headquarters/city jail.