At his live shows, he has stated his support towards the oppressed indigenous people who struggle against racism in his "homeland of Chiapas, the rest of Mexico, and across the Americas".

Its booklet included a powerful photo collection of the Chiapas' movement, taken by the renowned Mexican photographer, Marco Antonio Cruz—winner of the Grange Prize in Canada and photography director of the political magazine Proceso in Mexico City.

He presented Day of the Dead: Heroes, a multi-disciplinary show created and curated by Escamilla himself, that included elements of theatre, dance, story-telling, gastronomy and music.

While committed to support socio-political causes throughout his music, Quique dedicated his performance and this special occasion to remember and honour some departed world figures who have fearlessly fought or given their lives to stand up for either justice, freedom, peace or equality such as Martin Luther King Jr., Emiliano Zapata, Malcolm X, Ché Guevara, Salvador Allende and Nelson Mandela; as well as modern-day activists who were and continue to be persecuted or murdered for defending their ancestral land and human rights such as Berta Cáceres and Julián Carrillo.

In more recent years, he has appeared at major, international folk, blues and jazz festivals, sharing stages with world-class artists of diverse genres such as Los Lobos, Michael Franti, Gustavo Santaolalla, Cyril Neville and the Royal Southern Brotherhood, Mokoomba, Calypso Rose, Bonnie Raitt, Serena Ryder, Ron Sexsmith, Kobo Town, Alabama Shakes, Alex Cuba, Buffy Sainte-Marie, Fred Penner, Los Texmaniacs and Puerto Candelaria.

In September 2021, Quique Escamilla created and directed the first edition of Tlalli, a festival dedicated to honouring and celebrating a multi-millenary-old connection that exists among the wide family of Indigenous Peoples across the Americas: from Guaranís in Brazil, Incas in Perú, Aztecs in México, to Six Nations in Canada and beyond.