On 23 January 2014, Régis was sold to an investment fund, being assigned to Chapecoense for six months.

[3] On 2 July, however, after being the top goalscorer of the year's Campeonato Catarinense, he signed a four-year deal with Sport.

[4] Régis scored his first Série A goal on 17 August 2014, netting the equalizer in a 1–1 home draw against Atlético Paranaense.

On 18 December 2015, Régis signed a one-year loan deal with Palmeiras, who overcame Santos for his signature.

[6] He signed a permanent contract with the club in 2018, and in March 2019, after a temporary deal at Al-Wehda, he joined Corinthians on loan until December.