Río Jacaguas is a river shared between the municipalities of Ponce and Juana Díaz in Puerto Rico.

It flows from north to south, draining into the Caribbean Sea east of the city of Ponce.

One of the 14 rivers in the municipality of Ponce, it is also the longest, at 39.72 kilometers (24.68 mi).

[5] Jacaguas has its origin in the municipality of Villalba, Puerto Rico, in the boundary between barrio Vacas and barrio Hato Puerco Arriba,[6] at an altitude of approximately 2,099 feet (640 m) above sea level.

It crosses the municipalities of Villalba and Juana Díaz, forming the Guayabal Lake, before approaching the municipality of Ponce where it becomes the boundary between Ponce and Juana Díaz most of its trajectory.