[2] Otero joined the youth sides of Caracas FC at the age of 15, and made his senior debut on 3 September 2009, coming on as a second-half substitute for Jesús Gómez in a 1–1 Primera División away draw against Llaneros.

[6] He made his debut with the club on 8 August, replacing Mikel Arguinarena and scoring the equalizer in a 2–1 home win over Deportes Iquique.

[9] He made his debut for the club on 4 August, replacing Robinho in a 2–1 away win over São Paulo, and scored his first goal in Brazil on 12 September, netting his team's second in a 3–2 away loss to Fluminense.

[12][13] Back to Atlético in July 2019, Otero featured regularly for the remainder of the year, but saw his playing time being drastically reduced in the 2020 season.

[14] On 24 August 2020, Otero was loaned to fellow top tier side Corinthians until July 2021; he also became the first Venezuelan player to play for the club.

[22] Otero received his first call-up for the Venezuela national team on 9 March 2013, for two 2014 FIFA World Cup qualifiers against Argentina and Colombia.