Rēzekne county (Latvian: Rēzeknes apriņķis) was a historic county in the Vitebsk Governorate, and in the Republic of Latvia dissolved during the administrative territorial reform of the Latvian SSR in 1949.

Established in 1629 as one of the subdivisions of the Inflanty Voivodeship (powiat rzeżycki).

After signing of the Latvian–Soviet Peace Treaty, Rēzeknes apriņķis was incorporated into the Republic of Latvia.

At the time of the Russian Empire Census of 1897, Rezhitsky Uyezd had a population of 136,445.

Of these, 57.9% spoke Latvian, 23.9% Russian, 7.4% Yiddish, 5.4% Belarusian, 4.8% Polish, 0.4% German, 0.1% Lithuanian and 0.1% Romani as their native language.