The R33 is a provincial route in South Africa that connects Pietermaritzburg with Lephalale via Greytown, Paulpietersburg, Carolina, Belfast and Vaalwater.

After crossing the Mokolo River, the R33 turns south-east and heads for 85 kilometres, through the Grootwater Nature Reserve, to the town of Vaalwater, where it meets the eastern terminus of the R517.

It continues south-east for 63 kilometres to the town of Modimolle (formerly known as Nylstroom), entering the vicinity as Nelson Mandela Drive.

It continues for 52 kilometres, bypassing the Westoe Dam, to the town of Amsterdam, where it reaches a 4-way junction with the R65 road.

[1] From the N2 split in Piet Retief, the R33 continues southwards for 45 kilometres, crossing the Pongola River into the KwaZulu-Natal Province, to the town of Paulpietersburg, where it makes a left and a right turn.

[1] West of Vryheid Central, the R33 meets the R34 at a 4-way junction and they become cosigned on the road leaving the city to the west-south-west.

It continues south-south-east for 124 kilometres, through Helpmekaar and Pomeroy, crossing the Tugela River, to the town of Greytown, where it meets the R74 road at a t-junction.