The R344 is a Regional Route in South Africa that connects Grahamstown with Dordrecht.

It heads south-west, crossing the N6 to reach Sterkstroom.

It leaves the town heading south-west to reach Tarkastad.

It reaches the R63 just west of Adelaide and together they head east into the town.

East of the town, the road leaves heading south to its southern terminus at the R350 between Grahamstown and Riebeek East.