The R345 is a Regional Route in South Africa that connects the R72 near Bell in the Ngqushwa Local Municipality with Cathcart passing through Peddie, the Great Fish River Nature Reserve, Alice and Hogsback.

[2] In the eighties, the route started in Hamburg;[3] however, this section is no longer part of the R345 by 2012.

[2] From its southern origin, the route heads northwest to Peddie, were it cross the N2.

It continues north to Alice, were it is co-signed with the R63 for a 9.6 km long section heading east.

In the eighties, the route started from Hamburg and was co-signed between Bell and the current terminus 4.2 km north of the settlement.