The R346 is a Regional Route in Eastern Cape, South Africa that connects Stutterheim with East London Airport via King William’s Town.

It heads south-south-west through Braunschweig to King William's Town (Qonce), where it enters as Alexander Avenue and meets the N2 and the R63 at the four-way junction with Maitland Road.

[2] The R346 leaves the town heading south-south-east to pass through Zwelitsha, where it meets the R102 to Phakamisa and crosses the Buffalo River.

It continues south, then east (meeting the M25 to Kidd's Beach), to reach a T-junction with the M5 (Buffalo Pass).

The R346 takes over as the Buffalo Pass and heads southwards to reach its end at a junction with the R72 approximately 2 kilometres west of King Phalo Airport in East London.