The R353 is a Regional Route in South Africa that connects Leeu-Gamka with Brandvlei via Fraserburg and Williston.

[1] Its north-eastern terminus is the R357 at Brandvlei, Northern Cape.

It initially heads south, then south-east to Williston where it meets the R63.

It crosses at a staggered junction, and continues south-east to Fraserburg.

At Fraserburg it crosses the R356 at another staggered junction.