The R355 is a Regional Route in South Africa that connects the R46 near Ceres with Kleinsee via Calvinia and Springbok.

[1] The route starts in the town of Kleinsee, Northern Cape, heading eastwards.

The R355 then emerges and heads east-south-east, returning to the Northern Cape, to meet the R357.

From Loeriesfontein, the R355 diverges heading south, before veering east to reach Calvinia.

The route continues south and meets the south-west origin of the R356 shortly before ending itself at the R46 between Ceres and Touws River.