The R357 is a Regional Route in South Africa that connects Nieuwoudtville and Kimberley via Loeriesfontein and Prieska.

It reaches Vanwyksvlei, where it meets the R361 and it joins the R361 to be co-signed to the north-east.

Just before the town, it meets the north-easterly R386 at its northern terminus.

It continues for about another 100 kilometres to cross the Orange River and reach Douglas.

From Douglas, it continues east-north-east to meet the R31 and end at the N8 in Kimberley.