The R43 is a provincial route in the Western Cape province of South Africa which connects Ceres with Gansbaai via Worcester, Botrivier and Hermanus.

From Worcester, it heads south for 50 kilometres, bypassing the Brandvlei Dam, to Villiersdorp, where it meets the south-western terminus of the R45.

The R43 joins the N2 westwards for 9 kilometers to Botrivier, where it splits from the N2 and continues southwards for 9 kilometres, following the Bot River and bypassing the Hottentots Holland Mountains, to meet the southern terminus of the R44.

From Hermanus, the route continues eastwards, bypassing the Klein River Lagoon, to reach Stanford, where it turns to the south again, meeting the coast at Gansbaai.

From Gansbaai, it continues east-south-east along the coast, bypassing Hydra Bay and Pearly Beach, to end in open countryside at Die Dam, close to the entrance to the Quoin Point section of the Walker Bay Nature Reserve.