[1] The R544 heads northwards to cross the Olifants River at the town of Vandyksdrif before it intersects with the western terminus of the R542.

It continues to intersect with the southern terminus of the R575 and crosses the Olifants River one more time.

It continues to cross under the N12 highway and heads into the southern suburbs of Witbank (eMalahleni) as Watermeyer Street.

The road leaves Witbank in a north-westerly direction as Carmen Street before heading north and eventually crossing the Wilge River.

The road's northern terminus is reached as it ends at a junction with the R573 just south-west of Kwaggafontein.