The R549 is a Regional Route in South Africa that connects Heidelberg in Gauteng with Deneysville in the Free State.

[1] Its northern terminus is a junction with the R23 in Heidelberg from which it heads south-west.

It bypasses Ratanda, crosses the Suikerbosrand River and meets the R54 road before crossing the Vaal River west of the Vaal Dam into the Free State and reaching an intersection with the R716 in Deneysville, marking its end.

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