The R580 is a Regional Route in Mpumalanga, South Africa that connects the R50 north of Leandra with Secunda and Evander.

It runs eastwards for 21 kilometres to reach a junction just before Matla Power Station, where it turns to the south.

It continues southwards for 12 kilometres to reach the Leven Station interchange, where it meets the eastern terminus of the R29 and crosses the N17 Highway.

It continues south for 4 kilometres to reach a junction just north-west of the industrial town of Secunda (west of Trichardt), where it turns to the west.

It heads for 4 kilometres to end at an intersection with the R546 south of Evander.